Posted 29 June 2023

A single gene could hold the answer to a number of conditions

New research out of Associate Professor Wayne Crismani and Dr Davis McCarthy’s labs could be the answer to a number of genetic conditions such as trisomy 21.

Led by talented PhD’s, Vanessa Tsui and Ruqian Lyu, the collaborative research project identified that a gene called FANCM, which is required for normal fertility levels, is involved in how our genes are passed down from one generation to the next.

Our genetics are shuffled between generations and when this shuffling goes wrong, we can inherit an extra chromosome or part thereof. This can lead to conditions like trisomy 21. The team have identified that FANCM controls these rates of shuffling which will allow us to learn more about the transmission of chromosomes from one generation to the next and could, ultimately, lead to cures for a range of inherited conditions.

This research has been published in Cell Genomics.