The proposed research student project centers on exploring the potential of saturation genome editing as a powerful tool for understanding gene function and regulation in complex biological systems. Leveraging the advancements in CRISPR-based technologies, the project aims to systematically introduce diverse and targeted mutations in specific important human genes. By employing high-throughput screening approaches and bioinformatics analyses, the student will comprehensively assess the phenotypic consequences of the introduced mutations, shedding light on essential genetic elements, regulatory networks, and disease-associated genes.

This project’s outcomes hold tremendous promise for uncovering novel gene interactions, elucidating functional pathways, and providing valuable insights into the genetic basis of various biological processes, thus contributing to the advancement of both fundamental research and therapeutic applications.

Supervised by

Wayne Crismani
Wayne Crismani

Head, DNA Repair & Recombination

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[email protected]

Available for Student Supervision