The mechanisms that control the quantity of mineral crystals that are incorporated into the skeleton are poorly understood, even though this is a major contributor to bone strength. Our recent discoveries indicate that intracellular vesicles, including lysosomes, are involved in mineral secretion by osteoblasts (boneforming cells) and osteocytes (cells embedded in the bone). This project will use cell culture techniques, gene knockdown studies, and cell-based assayssuch as confocal immunofluorescence, molecular biology, reporter assays, and quantitative PCR techniques to determine the function of lysosomes in osteocytes and osteoblasts. 

Supervised by

Natalie Sims
Natalie Sims

Head, Bone Cell Biology & Disease Laboratory

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[email protected]

+61 3 9231 2480

Available for Student Supervision