Mitochondria, the powerhouses of the cell, are organelles that provide cells with the essential chemical energy they need for almost all biochemical processes. The mitochondrial network is maintained by a precise equilibrium between fission and fusion events, dysregulation of which leads to poor mitochondrial health associated with many diseases. Our recent discoveries regarding how the enzyme DRP1 – the effector of mitochondrial fission and a direct AMPK substrate – is directly regulated by lipids opens up exciting avenues for research into DRP1 biology and the effects of obesity on mitochondria. See Rosdah et al, Pharmacology and Therapeutics, 213:107594 (2020).
You will receive applicable training from experts in biochemistry, cell biology, mass spectrometry and animal models. The team strives to maintain a highly supportive and inclusive research environment and adopts a collaborative approach. Our studies are regularly published in high impact journals.