mTORC1-AMPK signalling

AMPK is a serine/threonine protein kinase with central roles in cellular metabolism. AMPK acts as a node for multiple signalling inputs (e.g. phosphorylation, ubiquitination), however understanding of the functional and biological consequences of these modifications is very limited. Expanding on our recent discovery that AMPK is a direct substrate for the mTORC1 kinase, this exciting project will discover new aspects of AMPK regulation that may underpin new treatments for cancer. See Ling et al, Nature Metabolism 2(1):41-49 (2020). 

You will receive applicable training from experts in biochemistry, cell biology, mass spectrometry and animal models. The team strives to maintain a highly supportive and inclusive research environment and adopts a collaborative approach. Our studies are regularly published in high impact journals.