The student research project aims to establish a novel breast cancer mouse model to investigate the potential tumor suppressor role of a specific gene in breast cancer development and progression. Through genetic engineering techniques, the student will generate a cohort of mice with targeted deletion or mutation of the gene of interest within mammary epithelial cells. The resulting mouse model will be carefully characterized and monitored for the development of breast tumors and metastasis. Histopathological, molecular, and functional analyses will be conducted to assess tumor growth, cellular behavior, and the impact of the gene manipulation on tumor suppression.
By elucidating the gene’s potential role as a tumor suppressor in breast cancer, this project has the potential to provide crucial insights into the underlying mechanisms of tumorigenesis and may offer new opportunities for targeted therapeutic interventions.