Aicardi-Goutières syndrome (AGS) is a rare and progressive neurodevelopmental disorder that affects the brain and the immune system. The condition is believed to be caused by a genetic mutation that disrupts the normal function of certain genes involved in the immune response to viral infections. AGS can present in infancy or early childhood, and symptoms can include an enlarged head, seizures, developmental delay, and skin changes. There is currently no cure for AGS, and treatment is focused on managing symptoms, preventing complications, and providing supportive care such as physical therapy, speech therapy, and special education. As AGS is a rare and complex disease, early detection and diagnosis is crucial to ensure the best possible outcomes for those affected by the condition.
Cancer & RNA Biology
We are interested in understanding the regulation of RNA and how this is important in normal development and cancer. It is now recognised that RNA is actively regulated at many levels, and this is important for the function both normal cells and in cancer.Lab head: Professor Carl Walkley