Structural Immunobiology
We aim to reveal the way immune cells – with particular emphasis on ‘natural killer’ cells – communicate with their environment. We wish to harness this information to improve diagnosis and treatment of diseases such as leukaemia, HTLV1 infection, multiple sclerosis and psoriasis.
Lab head: Dr Julian VivianMeasuring islet-antigen specific regulatory T-cell (Treg) function in human type 1 diabetes.
T cell exhaustion in autoimmune diabetes
Clinical research using data and samples from clinical trials
Identifying IL-27 dependent pathogenic mechanisms in Type 1 Diabetes
Impact of JAK inhibitors on T-cell exhaustion and other immune regulatory mechanisms
Mechanisms of Regulatory T cell action in Type 1 Diabetes
Inducing T-cell exhaustion to prevent type 1 diabetes
Understanding the functions of IL-17 family receptors in type 1 diabetes
Concurrent analysis of T-cell exhaustion in islet and tumour microenvironments in a novel tumour model in NOD mice
Recurrence of type 1 diabetes in transplanted autologous beta cells
Using JAK inhibitors with locally delivered immunosuppression to target islet graft rejection
RNA & T Cell Biology
We interrogate the genetic mechanisms that control development of the immune system, to better understand human health and disease.
Lab head: Associate Professor Mark Chong